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SCENARIOS
Harry Sarimveis@hsarimv
SCENARIOS is a 4-year H2020 Research and Innovation project (RIA) involving 19 partners from 10 European countries and Israel. The goal is to close the knowledge gap and achieve breakthrough TRL advances in the toxicology, detection and remediation of probably the most objectionable and widespread class of contaminants -PFAS-, with an unprecedented energetic balance and virtually no external chemical additives. A major effort is underway to develop Integrated Approaches to Testing and Assessment (IATA) of PFAS, including the new generation of congeners, to assist EC and EU countries in decision-making on these substances for environmental safety and human health
For more information visit https://scenarios-project.eu/
| Title | Model Description |
| Extended PFOA male rat PBK | This is a PBK model that predicts the biodistribution of PFOA in rats after oral exposure or IV injection |
| PFOA rat_Worley | This is a PBK model that predicts the biodistribution of PFOA in rats after oral exposure or IV injection |
| PFASs Human PBPK | This is a PBK model that predicts the biodistribution of PFBS, PFHxS, PFOS, PFDS, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA or PFTeDA in humans after oral exposure |
| PFAAs Protein-Binding Fish PBK | This is a PBK model that predicts the biodistribution of PFOS, PFOA, PFDA, PFUnA, PFDoA or PFHxS in fish after waterborne exposure |
| PFOS/PFOA Human PBPK (Oral exposure) | This is a PBPK model that predicts the accumulation of PFOS or PFOA in humans after oral exposure |
| PFOS/PFOA Human PBK | This is a PBK model that predicts the biodistribution of PFOS or PFOA in humans after oral exposure or IV injection |
| PFOA rat PBK | This is a PBK model that predicts the biodistribution of PFOA in rats after oral exposure or IV injection |
| PFOS rat PBK | This is a PBK model that predicts the biodistribution of PFOS in rats after oral exposure or IV injection |
| PFHxS rat PBK | This is a PBK model that predicts the biodistribution of PFHxS in rats after oral exposure or IV injection |
| PFNA rat PBK | This is a PBK model that predicts the biodistribution of PFNA in rats after oral exposure or IV injection |
| PFDA rat PBK | This is a PBK model that predicts the biodistribution of PFDA in rats after oral exposure or IV injection |
| PFAS PBK Zebrafish | This is a PBK model that predicts the biodistribution of PFOA, PFHpA, PFNA, PFHxS, or PFBS in zebrafish through waterborne exposure |
| PFOA multi-route PBK rats- Tsiros (2025) | Multi-route permeability-limited PBK model for describing PFOA biodistribution in rats |
| Albumin binding QSAR model | This model predicts the logarithm (Log10) of the association constant (K_a) for the binding of PFAS to human serum albumin (HSA) |