Test# PBK model for PFNA biodistribution in rats

This Physiologically Based Kinetic (PBK) model has been developed by Kim et al. (2019) for describing the biodistribution of PFNA in rats after oral or iv exposure. The structural model considered is presented in the figure below
Using this web service, the user can run experiment and witness changes in the biodistribution of PFNA. The description and units of the state variables and independent model features can be found in the 'Features' tab. The user can set a constant body weight (BW), in which case BW.times should be set to zero. Alternatively, a vector of body weights can be provided using brackets, e.g. [0.23, 0.25, 0.30], in which case the corresponding time points when the body was measured (BW.times) should also be provided, e.g. [0,25,50]. Note that the two vectors should have equal length. The same principles should be followed for the dose and administrated dose (admin.dose) and administration.time (admin.dose) . The type of administration (admin.type) can be either iv or oral. Regarding the unabsorbed fraction following an oral administration (F_unabs), it was estimated to be 0.6 and 0.47 for male and female rats, respectively, by Kim et al. (2019), but the users are free to experiment with other values. Finally, the user should set a starting point (sim.start), time increment (sim.step) and last point (sim.end) for the simulation.
The R code used to deploy the model on Jaqpot can be found here. The model code is an R adaptation of the code of Bernstein et al. (2021).

Image taken directly from Bernstein et al. (2021).