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INSIGHT
Harry Sarimveis@hsarimv
INSIGHT is a project funded by Horizon Europe (GA101137742). The Project aims to:
- Develop an integrated framework for mechanistic impact assessment based on the novel concept of IOP;
- Provide curated and user-friendly FAIR data and computational models and workflows that support the development of the next generation SSbD chemicals and materials;
- Provide open, accessible and interactive guidelines, enabling end users and stakeholders to access and operate the framework.
For more information visit https://insight-project.org/
| Title | Model Description |
| Cell viability in graphene-related materials | QSAR-ML model for the prediction of cell viability (%) in graphene-related materials |
| Aquatic toxicity in fish species | This model predicts the aquatic toxicity (LC50) in fish species for small organic molecules |
| Aquatic toxicity in crustacean species | This model predicts EC50 in crustacean species for small organic molecules |
| QSAR toolbox Calculator integration | This service provides access to the calculators included in the QSAR toolbox |
| QSAR Toolbox Model Integration | This service provides access to the QSAR models included in the QSAR toolbox |
| QSAR Toolbox Profiler integration | This service provides access to the profilers included in the QSAR toolbox |
| Extended PFOA male rat PBK - NTUA (2024) | This is a PBK model that predicts the biodistribution of PFOA in rats after oral exposure or IV injection |
| PFOA rat - Worley and Fisher (2015) | This is a PBK model that predicts the biodistribution of PFOA in rats after oral exposure or IV injection |
| PFASs Human PBPK - Fabrega et al. (2025) | This is a PBK model that predicts the biodistribution of PFBS, PFHxS, PFOS, PFDS, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA or PFTeDA in humans after oral exposure |
| PFAAs Protein-Binding Fish PBK - Ng et al. (2013) | This is a PBK model that predicts the biodistribution of PFOS, PFOA, PFDA, PFUnA, PFDoA or PFHxS in fish after waterborne exposure |
| PFOS/PFOA Human PBPK (Oral exposure) - Fabrega et al. (2016) | This is a PBPK model that predicts the accumulation of PFOS or PFOA in humans after oral exposure |
| PFOS Rainbow trout PBTK - Vidal et al. (2020) | This is a PBK model that predicts the biodistribution of PFOS in R. trout after oral or waterborne exposure |
| PFOS/PFOA Human PBK - Loccisano et al. (2011) | This is a PBK model that predicts the biodistribution of PFOS or PFOA in humans after oral exposure or IV injection |
| PFOA rat PBK - Loccisano et al. (2012) | This is a PBK model that predicts the biodistribution of PFOA in rats after oral exposure or IV injection |
| PFOS rat PBK - Loccisano et al. (2012) | This is a PBK model that predicts the biodistribution of PFOS in rats after oral exposure or IV injection |
| PFHxS rat PBK - Kim et al. (2018) | This is a PBK model that predicts the biodistribution of PFHxS in rats after oral exposure or IV injection |
| PFNA rat PBK - Kim et al. (2019) | This is a PBK model that predicts the biodistribution of PFNA in rats after oral exposure or IV injection |
| PFDA rat PBK - Kim et al. (2019) | This is a PBK model that predicts the biodistribution of PFDA in rats after oral exposure or IV injection |
| PFAS PBK Zebrafish - Golosovskaia et al. (2024) | This is a PBK model that predicts the biodistribution of PFOA, PFHpA, PFNA, PFHxS, or PFBS in zebrafish through waterborne exposure |
| PFOA PBK Humans - Worley et al. (2017) | PBK model for describing the biodistribution of PFOA in humans after intravenous or oral administration |
| Toluene di-isocyanate (TDI) PBK for humans - Scholten et al. (2023) | This PBK model simulates the biodistribution and urinary excretion of toluene diisocyanate (TDI) and its metabolites (TDA) in humans following occupational exposure via inhalation and dermal routes |
| Acetone PBK for humans - Mork and Johanson (2006) | This PBK model describes the uptake, distribution, metabolism, and excretion of acetone in humans, with a particular focus on inhalation exposure |
| Ethylene Glycol PBK for humans - Corley et al. (2005) | This PBK model describes the absorption, distribution, metabolism, and excretion of ethylene glycol (EG) and its primary metabolite glycolic acid (GA) in humans, with a particular focus on inhalation exposure scenarios |
| PFOS PBK for humans -Chou and Lin (2019) | This model reproduces the PBK model of Chou and Lin (2019) for describing the biodistribution of PFOS in humans |
| PFAS toxicokinetics model -Chiu et al. (2022) | Toxicokinetics model for describing the serum concentration-time of PFOA, PFOS, PFNA or PFHxS in humans after ingestion |
| PFBS Human PBK -NTUA (2025) | This PBK model predicts the biodistribution of PFBS in humans after oral exposure |
| PFHxA Human PBK -NTUA (2025) | This PBK model predicts the biodistribution of PFHxA in humans after oral exposure |
| In vitro toxicokinetics model - Fischer et al. (2017) ) | Steady-state mass balance model that predicts the free chemical concentrations in the medium |