The model of this application is a deployment of the model published by Vidal et al. (2020) in the paper titled as "Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based
toxicokinetic model".

This PBTK model predicts the biodistribution of PFOS in Rainbow trout after both oral and dietary exposure. The model consists of 11 individual compartment. The model considers two possible elimination routes; urinary and fecal excretion. A detailed description of the model could be found in the paper of Vidal et al. (2020).

The input parameters admin.dose_dietary, admin.time_dietary, C_water and admin.time_oral must be considered as vectors. For example, let's consider that the concentration of PFOS in water (C_water) is 10 μg/L at the beginning of the simulation (admin.time_oral=0) and this remains constant for 2 hours. Now consider that at exactly at 2 hours from the beginning of the experiment the new concentration of PFOS in water (C_water) is 20 μg/L. In order to force this change of concentrations to the model, the C_water and admin.time_oral should be defined by the user as [10,20] and [0,2], respectively. The same method should be followed in case of exposure to multiple intravenous injections over time.

The R code of the model and the code to upload the model on Jaqpot are uploaded on github repository, which contains multiple published PBK models for PFAS and various organisms.

Image taken directly from Vidal et al. (2020).