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Graphene Oxide PBK model in mice for different biodistribution studies
Independent Features
| Name | Units | Range | Description | Type | Actions |
|---|---|---|---|---|---|
BW | kg | Total body weight of mouse | FLOAT | ||
admin.dose | ug | Administered dose | FLOAT | ||
admin.time | min | Administration time | FLOAT | ||
admin.type |
Mode of administration | CATEGORICAL | |||
sex | Sex of the mouse | CATEGORICAL | |||
study | Graphene oxide biodistribution studies in mice | CATEGORICAL | |||
sim.start | min | First point of the simulation time vector | FLOAT | ||
sim.end | min | Last point of the simulation time vecto | FLOAT | ||
sim.step | min | Time increment of the simulation time vector | FLOAT |
Dependent Features
| Name | Units | Description | Type | Actions |
|---|---|---|---|---|
| MBart | ug | Mass of Graphene Oxide in arterial blood | FLOAT | |
| MBven | ug | Mass of Graphene Oxide in venous blood | FLOAT | |
| MKi | ug | Mass of Graphene Oxide in kidney | FLOAT | |
| MLi | ug | Mass of Graphene Oxide in liver | FLOAT | |
| MSt | ug | Mass of Graphene Oxide in stomach | FLOAT | |
| MStL | ug | Mass of Graphene Oxide in stomach lumen | FLOAT | |
| MSIn | ug | Mass of Graphene Oxide in small intestine | FLOAT | |
| MLIn | ug | Mass of Graphene Oxide in large intestine | FLOAT | |
| MLn | ug | Mass of Graphene Oxide in lungs | FLOAT | |
| MSpl | ug | Mass of Graphene Oxide in spleen | FLOAT | |
| MH | ug | Mass of Graphene Oxide in heart | FLOAT | |
| MBr | ug | Mass of Graphene Oxide in brain | FLOAT | |
| MRe | ug | Mass of Graphene Oxide in Rest of Body | FLOAT | |
| Murine | ug | Mass of Graphene Oxide in urine | FLOAT | |
| Mfeces | ug | Mass of Graphene Oxide in feces | FLOAT | |
| Mper | ug | Mass of Graphene Oxide in peritoneal space | FLOAT | |
| CBven | ug/L | Concentration of Graphene Oxide in venous blood | FLOAT | |
| CBart | ug/L | Concentration of Graphene Oxide in arterial blood | FLOAT | |
| CKi | ug/L | Concentration of Graphene Oxide in kidney | FLOAT | |
| CLi | ug/L | Concentration of Graphene Oxide in liver | FLOAT | |
| CSt | ug/L | Concentration of Graphene Oxide in stomach | FLOAT | |
| CSIn | ug/L | Concentration of Graphene Oxide in small intestine | FLOAT | |
| CLIn | ug/L | Concentration of Graphene Oxide in large intestine | FLOAT | |
| CLn | ug/L | Concentration of Graphene Oxide in lungs | FLOAT | |
| CSpl | ug/L | Concentration of Graphene Oxide in spleen | FLOAT | |
| CH | ug/L | Concentration of Graphene Oxide in heart | FLOAT | |
| CBr | ug/L | Concentration of Graphene Oxide in brain | FLOAT | |
| CRe | ug/L | Concentration of Graphene Oxide in Rest of Body | FLOAT | |
| time | min | Simulation time vector | FLOAT |