PBK model for describing the biodistribution of TiO2 nanoparticles in rats after IV injection

This PBK model has been developed in order to describe the biodistribution of TiO2 nanoparticles in rats after intravenous injectιοn and is thoroughly presented in Tsiros et al. (2024). The model consists of 8 different compartments describing the mass distribution of the nanoparticles in various organs, namely Lungs, Gastrointestinal tract, Spleen, Liver, Kidney, Heart, Bone and Rest of the Body. There are also two blood compartments; the arterial and venous blood. Each compartment is divided into two sub-compartments (except arterial and venous blood), the capillary space and the tissue space of the organ.Fecal excretion is the only clearance route is considered. The dataset used in the model fitting process was drawn from the study of Kreyling et al. (2017).

End-users can acquire predictions by filling in the corresponding input in the 'Predict/Validate' tab. Note that the framework supports repeated dosing. Specifically, if more than one doses are to be provided to the model, these should be given in an array format, e.g. [10,10,10]. Make sure that the length of the dose array is equal to the length of the administration time array.