The model of this application is a deployment of the model published by Ng et al. (2013) in the paper titled as "Bioconcentration of Perfluorinated Alkyl Acids: How Important Is Specific Binding?".

This PBK model predicts the biodistribution of PFOS, PFOA, PFDA, PFUnA, PFDoA, PFHxS in fish, who are exposed via water. The model consists of 9 compartments. The only elimination route considered is renal elimination. A detailed description of the model is provided in Ng et al. (2013).

The R code of the model and the code to upload the model on Jaqpot are uploaded on github repository, which contains multiple published PBK models for PFAS and various organisms.

Note: The model has been developed from scratch based on the paper and its supplemental material. However, there are some points that are not clear about the values of a few parameters, so we were not able to fully reproduce the results of the paper.

Image taken directly from Ng et al. (2013).