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PFOS/PFOA Human PBK
Independent Features
| Name | Units | Range | Description | Type | Actions |
|---|---|---|---|---|---|
BW | kg | Total body weight of human. | FLOAT | ||
substance | Specify the substance of the simulations. The user should select either 'PFOS' or 'PFOA'. | CATEGORICAL | |||
admin.type | The type of exposure for the simulation. This variable should be set either as 'oral' for oral exposure simulations or 'iv' for intravenous injections simulation. | CATEGORICAL | |||
admin.dose | mg | The concentration in water when orally exposured or the total amount of substance administered via intravenous injection. | FLOAT_ARRAY | ||
admin.time | h | Time at which the subject is exposed to the selected substance. | FLOAT_ARRAY | ||
Drinking_rate | L/h (default value is 0.032) | Specify the rate at which the subject drinks water. | FLOAT | ||
sim.start | h | Initial time point of simulation. | FLOAT | ||
sim.end | h | Final time point of simulation. | FLOAT | ||
sim.step | h | The integration step of simulation. | FLOAT |
Dependent Features
| Name | Units | Description | Type | Actions |
|---|---|---|---|---|
| APlas | mg | Amount of PFAS in plasma | FLOAT | |
| AG | mg | Amount of PFAS in gut | FLOAT | |
| AL | mg | Amount of PFAS in liver | FLOAT | |
| AF | mg | Amount of PFAS in fat | FLOAT | |
| AK | mg | Amount of PFAS in kidneys | FLOAT | |
| Afil | mg | Amount of PFAS in filtrate | FLOAT | |
| AStore | mg | Amount of PFAS in urine storage | FLOAT | |
| AUrine | mg | Amount of PFAS in urine | FLOAT | |
| ASk | mg | Amount of PFAS in skin | FLOAT | |
| AR | mg | Amount of PFAS in rest-of-the-body | FLOAT | |
| C_water | mg/L | Concentration of PFAS in water | FLOAT | |
| CPlas | mg/L | Concentration of PFAS in plasma | FLOAT | |
| CG | mg/L | Concentration of PFAS in gut | FLOAT | |
| CL | mg/L | Concentration of PFAS in liver | FLOAT | |
| CF | mg/L | Concentration of PFAS in fat | FLOAT | |
| CK | mg/L | Concentration of PFAS in kidneys | FLOAT | |
| Cfil | mg/L | Concentration of PFAS in filtrate | FLOAT | |
| CSk | mg/L | Concentration of PFAS in skin | FLOAT | |
| CR | mg/L | Concentration of PFAS in rest-of-the-body | FLOAT | |
| time | h | Simulation time vector | FLOAT |