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Archived Model
This model has been archived and scheduled for deletion in 26 days. Contact the owner if you need access to this resource.Generic PFAS Human PBK Model
Independent Features
| Name | Units | Range | Description | Type | Actions |
|---|---|---|---|---|---|
BW | kg | Body weight of human subject | FLOAT | ||
chemical | Name of PFAS | CATEGORICAL | |||
ingestion | ug or ug/time scale | Amount of PFAS ingested
if bolus selected ingestion is in ug
if continuous selected ingestion is in ug/time scale | FLOAT_ARRAY | ||
ingestion_time | time scale | Ingestion timepoint of PFAS
if bolus is selected it describes the timepoint of ingestion
if continuous is selected it describes the timepoint of exposure change | FLOAT_ARRAY | ||
exp_type | Bolus describes ingestion of PFAS in a discrete manner,
Continuous describes PFAS exposure from dietary sources in an continuous manner | CATEGORICAL | |||
time_scale | User defined time scale, all calculations are based on the selected time scale | CATEGORICAL | |||
sim.start | time scale | Start of simulation | FLOAT | ||
sim.end | time scale | End of simulation | FLOAT | ||
sim.step | time scale | Simulation time step | FLOAT |
Dependent Features
| Name | Units | Description | Type | Actions |
|---|---|---|---|---|
| Atissue | ug | Amount of PFAS in whole body at a timepoint | FLOAT | |
| Aloss | ug | Amount of PFAS excreted at a timepoint | FLOAT | |
| Atotal | ug | Total amount of PFAS ingested at a timepoint | FLOAT | |
| CR | ug/L tissue | Concentration in the rest of the body compartment | FLOAT | |
| CAdi | ug/L tissue | Concentration in the adipose tissue | FLOAT | |
| CBra | ug/L tissue | Concentration in brain tissue | FLOAT | |
| CGon | ug/L tissue | Concentration in gonad tissue | FLOAT | |
| CHea | ug/L tissue | Concentration in heart tissue | FLOAT | |
| CLun | ug/L tissue | Concentration in lung tissue | FLOAT | |
| CMus | ug/L tissue | Concentration in muscle tissue | FLOAT | |
| CSki | ug/L tissue | Concentration in skin tissue | FLOAT | |
| CSpl | ug/L tissue | Concentration in spleen tissue | FLOAT | |
| Cpan | ug/L tissue | Concentration in pancreas tissue | FLOAT | |
| CKb | ug/L kidney | Concentration in kidney plasma | FLOAT | |
| CVK | Plasma concentration leaving kidney | FLOAT | ||
| CPTC | ug/L tissue | Concentration in proximal tubule cells | FLOAT | |
| CL | ug/L tissue | Concentration in liver tissue | FLOAT | |
| CGI | ug/L tissue | Concentration in gastrointestinal tract tissue | FLOAT | |
| CA | ug/L plasma | Concentration in plasma compartment | FLOAT | |
| Afeces | ug excreted | Cumulative amount of PFAS excreted via feces | FLOAT | |
| Aurine | ug excreted | Cumulative amount of PFAS excreted via urine | FLOAT | |
| time | time scale | FLOAT |