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IndusChemFate PBTK
Independent Features
| Name | Units | Range | Description | Type | Actions |
|---|---|---|---|---|---|
dens_0 | mg/cm^3 or g/L | Density of substance 0 | FLOAT | ||
mw_0 | g/mol | Molecular Weight of substance 0 | FLOAT | ||
vpPa_0 | Pa | Vapor Pressure of substance 0 | FLOAT | ||
lkow_0 | Log(Kow) of substance 0 in blood (pH=7.4) | FLOAT | |||
DermLKow | Log(Kow) of substance 0 in skin (pH=5.5) | FLOAT | |||
wsol_0 | mg/L | Water solubility of substance 0 | FLOAT | ||
Resorpt_0 | - | Resorption tubuli fraction of substance 0 | FLOAT | ||
FracHpRt_0 | - | Enterohepatic removal fraction for substance 0 (relative to liver venous blood) | FLOAT | ||
dens_1 | mg/cm^3 or g/L | Density of substance 1 | FLOAT | ||
mw_1 | g/mol | Molecular Weight of substance 1 | FLOAT | ||
vpPa_1 | Pa | Vapor Pressure of substance 1 | FLOAT | ||
lkow_1 | Log(Kow) of substance 1 in blood (pH=7.4) | FLOAT | |||
wsol_1 | mg/L | Water solubility of substance 1 | FLOAT | ||
Resorpt_1 | - | Resorption tubuli fraction of substance 1 | FLOAT | ||
FracHpRt_1 | - | Enterohepatic removal fraction for substance 1 (relative to liver venous blood) | FLOAT | ||
dens_2 | mg/cm^3 or g/L | Density of substance 2 | FLOAT | ||
mw_2 | g/mol | Molecular weight of substance 2 | FLOAT | ||
vpPa_2 | Pa | Vapor pressure of substance 2 | FLOAT | ||
lkow_2 | Log(Kow) in blood for substance 2 (pH=7.4) | FLOAT | |||
wsol_2 | mg/L | Water solubility of substance 2 | FLOAT | ||
Resorpt_2 | - | Resorption tubuli fraction of substance 2 | FLOAT | ||
FracHpRt_2 | - | Enterohepatic removal fraction for substance 2 (relative to liver venous blood) | FLOAT | ||
dens_3 | mg/cm^3 or g/L | Density of substance 3 | FLOAT | ||
mw_3 | g/mol | Molecular weight of substance 3 | FLOAT | ||
vpPa_3 | Pa | Vapor pressure of substance 3 | FLOAT | ||
lkow_3 | Log(Kow) in blood for substance 3 (pH=7.4) | FLOAT | |||
wsol_3 | mg/L | Water solubility of substance 3 | FLOAT | ||
Resorpt_3 | - | Resorption tubuli fraction of substance 3 | FLOAT | ||
FracHpRt_3 | - | Enterohepatic removal fraction for substance 3 (relative to liver venous blood) | FLOAT | ||
dens_4 | mg/cm^3 or g/L | Density of substance 4 | FLOAT | ||
mw_4 | g/mol | Molecular weight of substance 4 | FLOAT | ||
vpPa_4 | Pa | Vapor pressure of substance 4 | FLOAT | ||
lkow_4 | Log(Kow) in blood for substance 4 (pH=7.4) | FLOAT | |||
wsol_4 | mg/L | Water solubility of substance 4 | FLOAT | ||
Resorpt_4 | - | Resorption tubuli fraction of substance 4 | FLOAT | ||
FracHpRt_4 | - | Enterohepatic removal fraction for substance 4 (relative to liver venous blood) | FLOAT | ||
scenario | - | Organism for the simulation Human Subjects 1. Normal man (in rest) - 70 kg 2. Obese man (in rest) - 80 kg 3. Normal man (light work) - 70 kg 4. Obese man (light work) - 80 kg 5. Normal woman (in rest) - 60 kg 6. Obese woman (in rest) - 70 kg 7. Normal woman (light work) - 60 kg 8. Obese woman (light work) - 70 kg 9. Normal child (in rest) - 16 kg 10. Obese child (in rest) - 20 kg 11. Normal child (playing) - 16 kg 12. Obese child (playing) - 20 kg Experimental Animals 13. Mouse (experimental study)- 0.03 kg 14. Rat (experimental study) - 0.3 kg
| INTEGER | ||
body_weight | Kg | Body weight of organism | FLOAT | ||
Temp | °C | Skin Temperature (Usually 25 °C) | FLOAT | ||
SkinArea | cm2 | Affected skin area | FLOAT | ||
RespProt | - | Respiratory protection factor | FLOAT | ||
DermProt | - | Dermal protection factor (air tight clothing) | FLOAT | ||
DecrBolusRt | 1/hour | Absorption rate into intestinal tissue | FLOAT | ||
N_subs | - | Number of substances in the simulation. 1 -> Simulate only parent substance (substance 0) 2 -> Simulate parent substance and metabolite_1 (substances 0 and 1) 3 -> Simulate parent substance and metabolite_1 and metabolite_2 (substances 0, 1, 2) 4 -> Simulate parent substance and metabolite_1, metabolite_2 and metabolite_3 (substances 0, 1, 2, 3) 5 -> Simulate parent substance and metabolite_1, metabolite_2, metabolite_3 and metabolite_3 (substances 0, 1, 2, 3, 4) | FLOAT | ||
Cexp | mg/m3 | Concentration of parent substance in air (airborne exposure) | FLOAT | ||
Cexp_times | hours | Time points at which Cexp changes | FLOAT | ||
DeposRate | mg/cm2/hour | Skin Deposition rate of pure substance 0 (Dermal exposure) | FLOAT | ||
DeposRate_times | hours | Time points at which DeposRate changes | FLOAT | ||
OralDose | mg/kg bodyweight | Bolus dose to stomach of parent substance 0 | FLOAT | ||
OralDose_times | hours | Time points at which OralDose is administered | FLOAT | ||
Vmax_Adip_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Adipose (Decrease of substance 0) | FLOAT | ||
Vmax_Adip_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Adipose (Decrease of substance 1) | FLOAT | ||
Vmax_Adip_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Adipose (Decrease of substance 2) | FLOAT | ||
Vmax_Adip_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Adipose (Decrease of substance 3) | FLOAT | ||
Vmax_Adip_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Adipose (Decrease of substance 4) | FLOAT | ||
Vmax_Bone_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Bone (Decrease of substance 0)
| FLOAT | ||
Vmax_Bone_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Bone (Decrease of substance 1) | FLOAT | ||
Vmax_Bone_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Bone (Decrease of substance 2) | FLOAT | ||
Vmax_Bone_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Bone (Decrease of substance 3) | FLOAT | ||
Vmax_Bone_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Bone (Decrease of substance 4) | FLOAT | ||
Vmax_Brain_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Brain (Decrease of substance 0) | FLOAT | ||
Vmax_Brain_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Brain (Decrease of substance 1) | FLOAT | ||
Vmax_Brain_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Brain (Decrease of substance 2) | FLOAT | ||
Vmax_Brain_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Brain (Decrease of substance 3) | FLOAT | ||
Vmax_Brain_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Brain (Decrease of substance 4) | FLOAT | ||
Vmax_Heart_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Heart (Decrease of substance 0) | FLOAT | ||
Vmax_Heart_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Heart (Decrease of substance 1) | FLOAT | ||
Vmax_Heart_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Heart (Decrease of substance 2) | FLOAT | ||
Vmax_Heart_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Heart (Decrease of substance 3) | FLOAT | ||
Vmax_Heart_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Heart (Decrease of substance 4) | FLOAT | ||
Vmax_Kidney_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Kidney (Decrease of substance 0) | FLOAT | ||
Vmax_Kidney_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Kidney (Decrease of substance 1) | FLOAT | ||
Vmax_Kidney_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Kidney (Decrease of substance 2) | FLOAT | ||
Vmax_Kidney_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Kidney (Decrease of substance 3) | FLOAT | ||
Vmax_Kidney_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Kidney (Decrease of substance 4) | FLOAT | ||
Vmax_Intestine_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Instestine (Decrease of substance 0) | FLOAT | ||
Vmax_Intestine_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Intestine (Decrease of substance 1) | FLOAT | ||
Vmax_Intestine_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Instestine (Decrease of substance 2) | FLOAT | ||
Vmax_Intestine_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Instestine (Decrease of substance 3) | FLOAT | ||
Vmax_Intestine_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Instestine (Decrease of substance 4) | FLOAT | ||
Vmax_Liver_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Liver (Decrease of substance 0) | FLOAT | ||
Vmax_Liver_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Liver (Decrease of substance 1) | FLOAT | ||
Vmax_Liver_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Liver (Decrease of substance 2) | FLOAT | ||
Vmax_Liver_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Liver (Decrease of substance 3) | FLOAT | ||
Vmax_Liver_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Liver (Decrease of substance 4) | FLOAT | ||
Vmax_Lung_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Lung (Decrease of substance 0) | FLOAT | ||
Vmax_Lung_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Lung (Decrease of substance 1) | FLOAT | ||
Vmax_Lung_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Lung (Decrease of substance 2) | FLOAT | ||
Vmax_Lung_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Lung (Decrease of substance 3) | FLOAT | ||
Vmax_Lung_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Lung (Decrease of substance 4) | FLOAT | ||
Vmax_Muscle_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Muscle (Decrease of substance 0) | FLOAT | ||
Vmax_Muscle_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Muscle (Decrease of substance 1) | FLOAT | ||
Vmax_Muscle_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Muscle (Decrease of substance 2) | FLOAT | ||
Vmax_Muscle_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Muscle (Decrease of substance 3) | FLOAT | ||
Vmax_Muscle_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Muscle (Decrease of substance 4) | FLOAT | ||
Vmax_Skin_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Skin (Decrease of substance 0) | FLOAT | ||
Vmax_Skin_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Skin (Decrease of substance 1) | FLOAT | ||
Vmax_Skin_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Skin (Decrease of substance 2) | FLOAT | ||
Vmax_Skin_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Skin (Decrease of substance 3) | FLOAT | ||
Vmax_Skin_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Skin (Decrease of substance 4) | FLOAT | ||
Vmax_Marrow_0 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 0 in Bone Marrow (Decrease of substance 0) | FLOAT | ||
Vmax_Marrow_1 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 1 in Bone Marrow (Decrease of substance 1) | FLOAT | ||
Vmax_Marrow_2 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 2 in Bone Marrow (Decrease of substance 2) | FLOAT | ||
Vmax_Marrow_3 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 3 in Bone Marrow (Decrease of substance 3) | FLOAT | ||
Vmax_Marrow_4 | µmol/kg tissue/hr | Maximum velocity of metabolism of substance 4 in Bone Marrow (Decrease of substance 4) | FLOAT | ||
Vmax_p_Adip_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Adipose | FLOAT | ||
Vmax_p_Adip_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Adipose | FLOAT | ||
Vmax_p_Adip_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Adipose
| FLOAT | ||
Vmax_p_Adip_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Adipose
| FLOAT | ||
Vmax_p_Bone_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Bone | FLOAT | ||
Vmax_p_Bone_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Bone
| FLOAT | ||
Vmax_p_Bone_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Bone
| FLOAT | ||
Vmax_p_Bone_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Bone
| FLOAT | ||
Vmax_p_Brain_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Brain
| FLOAT | ||
Vmax_p_Brain_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Bone | FLOAT | ||
Vmax_p_Brain_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Bone
| FLOAT | ||
Vmax_p_Brain_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Bone
| FLOAT | ||
Vmax_p_Heart_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Heart
| FLOAT | ||
Vmax_p_Heart_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Heart | FLOAT | ||
Vmax_p_Heart_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Heart
| FLOAT | ||
Vmax_p_Heart_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Heart
| FLOAT | ||
Vmax_p_Kidney_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Kidney
| FLOAT | ||
Vmax_p_Kidney_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Kidney | FLOAT | ||
Vmax_p_Kidney_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Kidney
| FLOAT | ||
Vmax_p_Kidney_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Kidney
| FLOAT | ||
Vmax_p_Intestine_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Intestine | FLOAT | ||
Vmax_p_Intestine_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Intestine
| FLOAT | ||
Vmax_p_Intestine_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Intestine | FLOAT | ||
Vmax_p_Intestine_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Intestine
| FLOAT | ||
Vmax_p_Liver_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Liver
| FLOAT | ||
Vmax_p_Liver_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Liver
| FLOAT | ||
Vmax_p_Liver_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Liver
| FLOAT | ||
Vmax_p_Liver_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Liver
| FLOAT | ||
Vmax_p_Lung_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Lung
| FLOAT | ||
Vmax_p_Lung_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Lung | FLOAT | ||
Vmax_p_Lung_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Lung
| FLOAT | ||
Vmax_p_Lung_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Lung
| FLOAT | ||
Vmax_p_Muscle_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Muscle
| FLOAT | ||
Vmax_p_Muscle_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Muscle
| FLOAT | ||
Vmax_p_Muscle_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Muscle | FLOAT | ||
Vmax_p_Muscle_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Muscle
| FLOAT | ||
Vmax_p_Skin_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Skin
| FLOAT | ||
Vmax_p_Skin_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Skin
| FLOAT | ||
Vmax_p_Skin_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Skin
| FLOAT | ||
Vmax_p_Skin_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Skin
| FLOAT | ||
Vmax_p_Marrow_1 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 1 in Bone Marrow
| FLOAT | ||
Vmax_p_Marrow_2 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 2 in Bone Marrow | FLOAT | ||
Vmax_p_Marrow_3 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 3 in Bone Marrow | FLOAT | ||
Vmax_p_Marrow_4 | µmol/kg tissue/hr | Maximum velocity of metabolic production of substance 4 in Bone Marrow
| FLOAT | ||
Km_Adip_0 | µmol/litre | Michaelis-Menten constant of substance 0 in Adipose | FLOAT | ||
Km_Adip_1 | µmol/L | Michaelis-Menten constant of substance 1 in Adipose
| FLOAT | ||
Km_Adip_2 | mg/L | Michaelis-Menten constant of substance 2 in Adipose
| FLOAT | ||
Km_Adip_3 | µmol/L | Michaelis-Menten constant of substance 3 in Adipose
| FLOAT | ||
Km_Adip_4 | mg/L | Michaelis-Menten constant of substance 4 in Adipose
| FLOAT | ||
Km_Bone_0 | µmol/L | Michaelis-Menten constant of substance 0 in Bone
| FLOAT | ||
Km_Bone_1 | µmol/L | Michaelis-Menten constant of substance 1 in Bone
| FLOAT | ||
Km_Bone_2 | µmol/L | Michaelis-Menten constant of substance 2 in Bone
| FLOAT | ||
Km_Bone_3 | µmol/L | Michaelis-Menten constant of substance 3 in Bone
| FLOAT | ||
Km_Bone_4 | µmol/L | Michaelis-Menten constant of substance 4 in Bone
| FLOAT | ||
Km_Brain_0 | µmol/L | Michaelis-Menten constant of substance 0 in Brain
| FLOAT | ||
Km_Brain_1 | µmol/L | Michaelis-Menten constant of substance 1 in Brain
| FLOAT | ||
Km_Brain_2 | µmol/L | Michaelis-Menten constant of substance 2 in Brain
| FLOAT | ||
Km_Brain_3 | µmol/L | Michaelis-Menten constant of substance 3 in Brain
| FLOAT | ||
Km_Brain_4 | µmol/L | Michaelis-Menten constant of substance 4 in Brain
| FLOAT | ||
Km_Heart_0 | µmol/L | Michaelis-Menten constant of substance 0 in Heart
| FLOAT | ||
Km_Heart_1 | µmol/L | Michaelis-Menten constant of substance 1 in Heart
| FLOAT | ||
Km_Heart_2 | µmol/L | Michaelis-Menten constant of substance 2 in Heart
| FLOAT | ||
Km_Heart_3 | µmol/L | Michaelis-Menten constant of substance 3 in Heart
| FLOAT | ||
Km_Heart_4 | µmol/L | Michaelis-Menten constant of substance 4 in Heart
| FLOAT | ||
Km_Kidney_0 | µmol/L | Michaelis-Menten constant of substance 0 in Kidney
| FLOAT | ||
Km_Kidney_1 | µmol/L | Michaelis-Menten constant of substance 1 in Kidney
| FLOAT | ||
Km_Kidney_2 | µmol/L | Michaelis-Menten constant of substance 2 in Kidney
| FLOAT | ||
Km_Kidney_3 | µmol/L | Michaelis-Menten constant of substance 3 in Kidney
| FLOAT | ||
Km_Kidney_4 | µmol/L | Michaelis-Menten constant of substance 4 in Kidney
| FLOAT | ||
Km_Intestine_0 | µmol/L | Michaelis-Menten constant of substance 0 in Intestine
| FLOAT | ||
Km_Intestine_1 | µmol/L | Michaelis-Menten constant of substance 1 in Intestine
| FLOAT | ||
Km_Intestine_2 | µmol/L | Michaelis-Menten constant of substance 2 in Intestine
| FLOAT | ||
Km_Intestine_3 | µmol/L | Michaelis-Menten constant of substance 3 in Intestine
| FLOAT | ||
Km_Intestine_4 | µmol/L | Michaelis-Menten constant of substance 4 in Intestine
| FLOAT | ||
Km_Liver_0 | µmol/L | Michaelis-Menten constant of substance 0 in Liver
| FLOAT | ||
Km_Liver_1 | µmol/L | Michaelis-Menten constant of substance 1 in Intestine
| FLOAT | ||
Km_Liver_2 | µmol/L | Michaelis-Menten constant of substance 2 in Intestine
| FLOAT | ||
Km_Liver_3 | µmol/L | Michaelis-Menten constant of substance 3 in Intestine
| FLOAT | ||
Km_Liver_4 | µmol/L | Michaelis-Menten constant of substance 4 in Liver
| FLOAT | ||
Km_Lung_0 | µmol/L | Michaelis-Menten constant of substance 0 in Lung
| FLOAT | ||
Km_Lung_1 | µmol/L | Michaelis-Menten constant of substance 1 in Lung
| FLOAT | ||
Km_Lung_2 | µmol/L | Michaelis-Menten constant of substance 2 in Lung
| FLOAT | ||
Km_Lung_3 | µmol/L | Michaelis-Menten constant of substance 3 in Lung
| FLOAT | ||
Km_Lung_4 | µmol/L | Michaelis-Menten constant of substance 4 in Lung
| FLOAT | ||
Km_Muscle_0 | µmol/L | Michaelis-Menten constant of substance 0 in Muscle
| FLOAT | ||
Km_Muscle_1 | µmol/L | Michaelis-Menten constant of substance 1 in Muscle
| FLOAT | ||
Km_Muscle_2 | µmol/L | Michaelis-Menten constant of substance 2 in Muscle
| FLOAT | ||
Km_Muscle_3 | µmol/L | Michaelis-Menten constant of substance 3 in Muscle
| FLOAT | ||
Km_Muscle_4 | µmol/L | Michaelis-Menten constant of substance 4 in Muscle
| FLOAT | ||
Km_Skin_0 | µmol/L | Michaelis-Menten constant of substance 0 in Skin
| FLOAT | ||
Km_Skin_1 | µmol/L | Michaelis-Menten constant of substance 1 in Skin
| FLOAT | ||
Km_Skin_2 | µmol/L | Michaelis-Menten constant of substance 2 in Skin
| FLOAT | ||
Km_Skin_3 | µmol/L | Michaelis-Menten constant of substance 3 in Skin
| FLOAT | ||
Km_Skin_4 | µmol/L | Michaelis-Menten constant of substance 4 in Skin
| FLOAT | ||
Km_Marrow_0 | µmol/L | Michaelis-Menten constant of substance 0 in Bone Marrow
| FLOAT | ||
Km_Marrow_1 | µmol/L | Michaelis-Menten constant of substance 1 in Bone Marrow
| FLOAT | ||
Km_Marrow_2 | µmol/L | Michaelis-Menten constant of substance 2 in Bone Marrow
| FLOAT | ||
Km_Marrow_3 | µmol/L | Michaelis-Menten constant of substance 3 in Bone Marrow
| FLOAT | ||
Km_Marrow_4 | µmol/L | Michaelis-Menten constant of substance 4 in Bone Marrow
| FLOAT | ||
sim.start | hours | Initial time point of simulation
| FLOAT | ||
sim.end | hours | Final time point of simulation
| FLOAT | ||
sim.step | hours | Time step of simulation | FLOAT |
Dependent Features
| Name | Units | Description | Type | Actions |
|---|---|---|---|---|
| M_Adip_0 | μmol | Amount of substance 0 in adipose | FLOAT | |
| M_Adip_1 | μmol | Amount of substance 1 in adipose | FLOAT | |
| M_Adip_2 | μmol | Amount of substance 2 in adipose | FLOAT | |
| M_Adip_3 | μmol | Amount of substance 3 in adipose | FLOAT | |
| M_Adip_4 | μmol | Amount of substance 4 in adipose | FLOAT | |
| M_Bone_0 | μmol | Amount of substance 0 in bone | FLOAT | |
| M_Bone_1 | μmol | Amount of substance 1 in bone | FLOAT | |
| M_Bone_2 | μmol | Amount of substance 2 in bone | FLOAT | |
| M_Bone_3 | μmol | Amount of substance 3 in bone | FLOAT | |
| M_Bone_4 | μmol | Amount of substance 4 in bone | FLOAT | |
| M_Brain_0 | μmol | Amount of substance 0 in brain | FLOAT | |
| M_Brain_1 | μmol | Amount of substance 1 in brain | FLOAT | |
| M_Brain_2 | μmol | Amount of substance 2 in brain | FLOAT | |
| M_Brain_3 | μmol | Amount of substance 3 in brain | FLOAT | |
| M_Brain_4 | μmol | Amount of substance 04in brain | FLOAT | |
| M_Heart_0 | μmol | Amount of substance 0 in heart | FLOAT | |
| M_Heart_1 | μmol | Amount of substance 1 in heart | FLOAT | |
| M_Heart_2 | μmol | Amount of substance 2 in heart | FLOAT | |
| M_Heart_3 | μmol | Amount of substance 3 in heart | FLOAT | |
| M_Heart_4 | μmol | Amount of substance 4 in heart | FLOAT | |
| M_Kidney_0 | μmol | Amount of substance 0 in kidney | FLOAT | |
| M_Kidney_1 | μmol | Amount of substance 1 in kidney | FLOAT | |
| M_Kidney_2 | μmol | Amount of substance 2 in kidney | FLOAT | |
| M_Kidney_3 | μmol | Amount of substance 3 in kidney | FLOAT | |
| M_Kidney_4 | μmol | Amount of substance 4 in kidney | FLOAT | |
| M_Intestine_0 | μmol | Amount of substance 0 in intestine | FLOAT | |
| M_Intestine_1 | μmol | Amount of substance 1 in intestine | FLOAT | |
| M_Intestine_2 | μmol | Amount of substance 2 in intestine | FLOAT | |
| M_Intestine_3 | μmol | Amount of substance 3 in intestine | FLOAT | |
| M_Intestine_4 | μmol | Amount of substance 4 in intestine | FLOAT | |
| M_Liver_0 | μmol | Amount of substance 0 in liver | FLOAT | |
| M_Liver_1 | μmol | Amount of substance 1 in liver | FLOAT | |
| M_Liver_2 | μmol | Amount of substance 2 in liver | FLOAT | |
| M_Liver_3 | μmol | Amount of substance 3 in liver | FLOAT | |
| M_Liver_4 | μmol | Amount of substance 4 in liver | FLOAT | |
| Cinh_0 | μmol/L | Concentration of inhaled substance 0 (after applying the RespProt factor) | FLOAT | |
| M_Lung_0 | μmol | Amount of substance 0 in lung | FLOAT | |
| M_Lung_1 | μmol | Amount of substance 1 in lung | FLOAT | |
| M_Lung_2 | μmol | Amount of substance 2 in lung | FLOAT | |
| M_Lung_3 | μmol | Amount of substance 3 in lung | FLOAT | |
| M_Lung_4 | μmol | Amount of substance 4 in lung | FLOAT | |
| M_Muscle_0 | μmol | Amount of substance 0 in muscle | FLOAT | |
| M_Muscle_1 | μmol | Amount of substance 1 in muscle | FLOAT | |
| M_Muscle_2 | μmol | Amount of substance 2 in muscle | FLOAT | |
| M_Muscle_3 | μmol | Amount of substance 3 in muscle | FLOAT | |
| M_Muscle_4 | μmol | Amount of substance 4 in muscle | FLOAT | |
| M_Skin_0 | μmol | Amount of substance 0 in skin | FLOAT | |
| M_Skin_1 | μmol | Amount of substance 1 in skin | FLOAT | |
| M_Skin_2 | μmol | Amount of substance 2 in skin | FLOAT | |
| M_Skin_3 | μmol | Amount of substance 3 in skin | FLOAT | |
| M_Skin_4 | μmol | Amount of substance 4 in skin | FLOAT | |
| DeposRate | mg/cm2/hour | Skin Deposition rate of pure substance 0 (Dermal exposure) | FLOAT | |
| StratCornAdd | μmol | Added amount of substance 0 in Stratum Corneum (Dermal exposure) | FLOAT | |
| StratCornDecr | μmol | Decreased amount of substance 0 in Stratum Corneum (Dermal exposure) | FLOAT | |
| EvapReal | μmol | Evaporated amount of substance 0 from skin surface | FLOAT | |
| EvapSC | μmol | Evaporated amount of substance 0 from stratum corneum | FLOAT | |
| Sum_Skin_Air | µmol/Kg bodyweight | Total intake through skin from the airborne exposure | FLOAT | |
| Sum_Skin_Liq | µmol/Kg bodyweight | Total intake through skin from liquid deposition on skin | FLOAT | |
| M_Marrow_0 | μmol | Amount of substance 0 in bone marrow | FLOAT | |
| M_Marrow_1 | μmol | Amount of substance 1 in bone marrow | FLOAT | |
| M_Marrow_2 | μmol | Amount of substance 2 in bone marrow | FLOAT | |
| M_Marrow_3 | μmol | Amount of substance 3 in bone marrow | FLOAT | |
| M_Marrow_4 | μmol | Amount of substance 4 in bone marrow | FLOAT | |
| M_LungArt_0 | μmol | Amount of substance 0 flowing in arterial blood from lung | FLOAT | |
| M_LungArt_1 | μmol | Amount of substance 1 flowing in arterial blood from lung | FLOAT | |
| M_LungArt_2 | μmol | Amount of substance 2 flowing in arterial blood from lung | FLOAT | |
| M_LungArt_3 | μmol | Amount of substance 3 flowing in arterial blood from lung | FLOAT | |
| M_LungArt_4 | μmol | Amount of substance 4 flowing in arterial blood from lung | FLOAT | |
| M_LungVen_0 | μmol | Amount of substance 0 in venous blood flowing to lung | FLOAT | |
| M_LungVen_1 | μmol | Amount of substance 1 in venous blood flowing to lung | FLOAT | |
| M_LungVen_2 | μmol | Amount of substance 2 in venous blood flowing to lung | FLOAT | |
| M_LungVen_3 | μmol | Amount of substance 3 in venous blood flowing to lung | FLOAT | |
| M_LungVen_4 | μmol | Amount of substance 4 in venous blood flowing to lung | FLOAT | |
| UrinExcr_0 | μmol | Amount of substance 0 excreted through the urine | FLOAT | |
| UrinExcr_1 | μmol | Amount of substance 1 excreted through the urine | FLOAT | |
| UrinExcr_2 | μmol | Amount of substance 2 excreted through the urine | FLOAT | |
| UrinExcr_3 | μmol | Amount of substance 3 excreted through the urine | FLOAT | |
| UrinExcr_4 | μmol | Amount of substance 4 excreted through the urine | FLOAT | |
| M_inhaled_0 | μmol | Inhaled amount of substance 0 | FLOAT | |
| Μ_Exh_0 | μmol | Exhaled amount of substance 0 | FLOAT | |
| Μ_Exh_1 | μmol | Exhaled amount of substance 1 | FLOAT | |
| Μ_Exh_2 | μmol | Exhaled amount of substance 2 | FLOAT | |
| Μ_Exh_3 | μmol | Exhaled amount of substance 3 | FLOAT | |
| Μ_Exh_4 | μmol | Exhaled amount of substance 4 | FLOAT | |
| M_IntCav_0 | μmol | Amount of substance 0 in intestinal cavity (lumen) | FLOAT | |
| M_IntCav_1 | μmol | Amount of substance 1 in intestinal cavity (lumen) | FLOAT | |
| M_IntCav_2 | μmol | Amount of substance 2 in intestinal cavity (lumen) | FLOAT | |
| M_IntCav_3 | μmol | Amount of substance 3 in intestinal cavity (lumen) | FLOAT | |
| M_IntCav_4 | μmol | Amount of substance 4 in intestinal cavity (lumen) | FLOAT | |
| BolusDose | μmol | Amount of substance 0 in oral dose | FLOAT | |
| MassSurf | μmol | Amount of substance 0 on skin surface | FLOAT | |
| StratCorn | μmol | Amount of sabstance 0 in Stratum Corneum | FLOAT | |
| UrinVol | L | Urine Volume | FLOAT | |
| Sum_Bolus | µmol/Kg bodyweight | Total intake from oral doses | FLOAT | |
| C_Adip_0 | μmol/L | Concentration of substance 0 in adipose | FLOAT | |
| C_Adip_1 | μmol/L | Concentration of substance 1 in adipose | FLOAT | |
| C_Adip_2 | μmol/L | Concentration of substance 2 in adipose | FLOAT | |
| C_Adip_3 | μmol/L | Concentration of substance 3 in adipose | FLOAT | |
| C_Adip_4 | μmol/L | Concentration of substance 4 in adipose | FLOAT | |
| C_Bone_0 | μmol/L | Concentration of substance 0 in bone | FLOAT | |
| C_Bone_1 | μmol/L | Concentration of substance 1 in bone | FLOAT | |
| C_Bone_2 | μmol/L | Concentration of substance 2 in bone | FLOAT | |
| C_Bone_3 | μmol/L | Concentration of substance 3 in bone | FLOAT | |
| C_Bone_4 | μmol/L | Concentration of substance 4 in bone | FLOAT | |
| C_Brain_0 | μmol/L | Concentration of substance 0 in brain | FLOAT | |
| C_Brain_1 | μmol/L | Concentration of substance 1 in brain | FLOAT | |
| C_Brain_2 | μmol/L | Concentration of substance 2 in brain | FLOAT | |
| C_Brain_3 | μmol/L | Concentration of substance 3 in brain | FLOAT | |
| C_Brain_4 | μmol/L | Concentration of substance 4 in brain | FLOAT | |
| C_Heart_0 | μmol/L | Concentration of substance 0 in heart | FLOAT | |
| C_Heart_1 | μmol/L | Concentration of substance 1 in heart | FLOAT | |
| C_Heart_2 | μmol/L | Concentration of substance 2 in heart | FLOAT | |
| C_Heart_3 | μmol/L | Concentration of substance 3 in heart | FLOAT | |
| C_Heart_4 | μmol/L | Concentration of substance 4 in heart | FLOAT | |
| C_Kidney_0 | μmol/L | Concentration of substance 0 in kidney | FLOAT | |
| C_Kidney_1 | μmol/L | Concentration of substance 1 in kidney | FLOAT | |
| C_Kidney_2 | μmol/L | Concentration of substance 2 in kidney | FLOAT | |
| C_Kidney_3 | μmol/L | Concentration of substance 3 in kidney | FLOAT | |
| C_Kidney_4 | μmol/L | Concentration of substance 4 in kidney | FLOAT | |
| C_Intestine_0 | μmol/L | Concentration of substance 0 in intestine | FLOAT | |
| C_Intestine_1 | μmol/L | Concentration of substance 1 in intestine | FLOAT | |
| C_Intestine_2 | μmol/L | Concentration of substance 2 in intestine | FLOAT | |
| C_Intestine_3 | μmol/L | Concentration of substance 3 in intestine | FLOAT | |
| C_Intestine_4 | μmol/L | Concentration of substance 4 in intestine | FLOAT | |
| C_Liver_0 | μmol/L | Concentration of substance 0 in liver | FLOAT | |
| C_Liver_1 | μmol/L | Concentration of substance 1 in liver | FLOAT | |
| C_Liver_2 | μmol/L | Concentration of substance 2 in liver | FLOAT | |
| C_Liver_3 | μmol/L | Concentration of substance 3 in liver | FLOAT | |
| C_Liver_4 | μmol/L | Concentration of substance 4 in liver | FLOAT | |
| C_Lung_0 | μmol/L | Concentration of substance 0 in lung | FLOAT | |
| C_Lung_1 | μmol/L | Concentration of substance 1 in lung | FLOAT | |
| C_Lung_2 | μmol/L | Concentration of substance 2 in lung | FLOAT | |
| C_Lung_3 | μmol/L | Concentration of substance 3 in lung | FLOAT | |
| C_Lung_4 | μmol/L | Concentration of substance 4 in lung | FLOAT | |
| C_Muscle_0 | μmol/L | Concentration of substance 0 in muscle | FLOAT | |
| C_Muscle_1 | μmol/L | Concentration of substance 1 in muscle | FLOAT | |
| C_Muscle_2 | μmol/L | Concentration of substance 2 in muscle | FLOAT | |
| C_Muscle_3 | μmol/L | Concentration of substance 3 in muscle | FLOAT | |
| C_Muscle_4 | μmol/L | Concentration of substance 4 in muscle | FLOAT | |
| C_Skin_0 | μmol/L | Concentration of substance 0 in skin | FLOAT | |
| C_Skin_1 | μmol/L | Concentration of substance 1 in skin | FLOAT | |
| C_Skin_2 | μmol/L | Concentration of substance 2 in skin | FLOAT | |
| C_Skin_3 | μmol/L | Concentration of substance 3 in skin | FLOAT | |
| C_Skin_4 | μmol/L | Concentration of substance 4 in skin | FLOAT | |
| C_Marrow_0 | μmol/L | Concentration of substance 0 in bone marrow | FLOAT | |
| C_Marrow_1 | μmol/L | Concentration of substance 1 in bone marrow | FLOAT | |
| C_Marrow_2 | μmol/L | Concentration of substance 2 in bone marrow | FLOAT | |
| C_Marrow_3 | μmol/L | Concentration of substance 3 in bone marrow | FLOAT | |
| C_Marrow_4 | μmol/L | Concentration of substance 4 in bone marrow | FLOAT | |
| C_BlungVen_0 | μmol/L | Concentration of substance 1 in venous blood flowing to lung | FLOAT | |
| C_BlungVen_1 | μmol/L | Concentration of substance 1 in venous blood flowing to lung | FLOAT | |
| C_BlungVen_2 | μmol/L | Concentration of substance 2 in venous blood flowing to lung | FLOAT | |
| C_BlungVen_3 | μmol/L | Concentration of substance 3 in venous blood flowing to lung | FLOAT | |
| C_BlungVen_4 | μmol/L | Concentration of substance 4 in venous blood flowing to lung | FLOAT | |
| C_BlungArt_0 | μmol/L | Concentration of substance 0 flowing in arterial blood from lung | FLOAT | |
| C_BlungArt_1 | μmol/L | Concentration of substance 1 flowing in arterial blood from lung | FLOAT | |
| C_BlungArt_2 | μmol/L | Concentration of substance 2 flowing in arterial blood from lung | FLOAT | |
| C_BlungArt_3 | μmol/L | Concentration of substance 3 flowing in arterial blood from lung | FLOAT | |
| C_BlungArt_4 | μmol/L | Concentration of substance 4 flowing in arterial blood from lung | FLOAT | |
| Cblart_0 | μmol/L | Concentration of substance 0 in arterial blood | FLOAT | |
| Cblart_1 | μmol/L | Concentration of substance 1 in arterial blood | FLOAT | |
| Cblart_2 | μmol/L | Concentration of substance 2 in arterial blood | FLOAT | |
| Cblart_3 | μmol/L | Concentration of substance 3 in arterial blood | FLOAT | |
| Cblart_4 | μmol/L | Concentration of substance 4 in arterial blood | FLOAT | |
| Cblven_0 | μmol/L | Concentration of substance 0 in venous blood coming from all organs | FLOAT | |
| Cblven_1 | μmol/L | Concentration of substance 1 in venous blood coming from all organs | FLOAT | |
| Cblven_2 | μmol/L | Concentration of substance 2 in venous blood coming from all organs | FLOAT | |
| Cblven_3 | μmol/L | Concentration of substance 3 in venous blood coming from all organs | FLOAT | |
| Cblven_4 | μmol/L | Concentration of substance 4 in venous blood coming from all organs | FLOAT | |
| Calv_0 | μmol/L | Concentration of substance 0 in alveolar air | FLOAT | |
| Calv_1 | μmol/L | Concentration of substance 1 in alveolar air | FLOAT | |
| Calv_2 | μmol/L | Concentration of substance 2 in alveolar air | FLOAT | |
| Calv_3 | μmol/L | Concentration of substance 3 in alveolar air | FLOAT | |
| Calv_4 | μmol/L | Concentration of substance 4 in alveolar air | FLOAT | |
| C_Urine_0 | μmol/L | Concentration of substance 0 in urine | FLOAT | |
| C_Urine_1 | μmol/L | Concentration of substance 1 in urine | FLOAT | |
| C_Urine_2 | μmol/L | Concentration of substance 2 in urine | FLOAT | |
| C_Urine_3 | μmol/L | Concentration of substance 3 in urine | FLOAT | |
| C_Urine_4 | μmol/L | Concentration of substance 4 in urine | FLOAT | |
| SumTissues | µmol/Kg bodyweight | Total amount of all substances in all tissues | FLOAT | |
| SumExh | µmol/Kg bodyweight | Total amount of exhaled substances per Kg of bodyweight | FLOAT | |
| SumUrin | µmol/Kg bodyweight | Total amount of excreted through urine substances per Kg of bodyweight | FLOAT | |
| SumCav | µmol/Kg bodyweight | Total amount of substances in intestinal cavity (lumen) per Kg of bodyweight | FLOAT | |
| SumBlood | µmol/Kg bodyweight | Total amount of all substances in venous and arterial blood of all tissues per Kg of bodyweight | FLOAT | |
| Sum_Oral_Abs | µmol/Kg bodyweight | Total amount of orally absorbed amount per Kg of bodyweight | FLOAT | |
| Sum_Inhaled | µmol/Kg bodyweight | Total amount of inhaled substance per Kg of bodyweight | FLOAT | |
| Sum_Skin_Air | µmol/Kg bodyweight | Total intake through skin from the airborne exposure | FLOAT | |
| Sum_Skin_Liq | µmol/Kg bodyweight | Total intake through skin from liquid deposition on skin | FLOAT | |
| time | hours | time points of simulation | FLOAT |