PBK model for describing the biodistribution of PFOA in male rats after intravenous or oral administration

This PBK model has been developed in order to describe the biodistribution of PFOA in male rats after either intravenous or oral administration and is thoroughly presented in Tsiros et al. (2024). The model consists of 10 different compartments describing the distribution of PFOA in various organs, namely Lungs, Intestines, Stomach, Spleen, Liver, Kidneys, Heart, Gonads, Brain and Rest of the Body. There are also two plasma compartments; the arterial and venous plasma. Both renal and hepatobiliary eliminations are considered. High modelling resolution is used for the Kidneys compartment, in order to capture the complexity of the reabsorption process. The original model was presented Worley and Fisher (2015) and was extended using data drawn from Kudo et al. (2007) and Dzierlenga et al. (2020)

End-users can acquire predictions by filling in the corresponding input in the 'Predict' tab. Note that the framework supports repeated dosing. Make sure that the length of the dose array is equal to the length of the administration time array.