PBK model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans

This Physiologically Based Kinetic (PBK) model has been developed using radioactivity data resulting from inhalation of technetium- labelled carbon nanoparticles (5-10 nm) from healthy male volunteers (24 to 47 years old). Its schematic representation can be seen in the following figure. The detailed description of the PBK model can be found in Pery et al., 2009.
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The model considers a concentration for technetium bound to small particles, in other words labelled nanoparticles, and free technetium. Hence the web service reports both the concentration of free and bound technetium in each compartment, as well as the total technetium concentration which is calculated as the summation of the two technetium forms. The concentration that is related to technetium bound to large particles cannot translocate the air:blood barrier and, thus, only the bound and total amounts of the lungs and stomach lumen ( through translocation from the lungs) contain radiation intensity from technetium bound to large particles, which is considered constant over time.
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Using this web service, the user can run experiment and witness changes in the biodistribution of free ad bound technegas by changing the values of the calibrated parameters. The description, units and values related to the calibrated chemical-specific parameters are presented in Table 1, while the ones related to the physiological parameter are presented in Table 2. Note that in the publication, joint distributions were estimated by MCMC and the graphs were made using individual level values. Since these values were not reported, here we present only the population means.
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_{^{Image taken directly from Pery et al., 2009.}}
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Table 1. Calibrated parameters presented in Pery et al. (2009)

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Table 2. Physiological parameters used in Pery et al. (2009)

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